"Ambry Genetics"[submitter] AND "SDHC"[gene] - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 1750990	NM_003001.5(SDHC):c.-5C>T	SDHC	Single nucleotide variant (5 prime UTR variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 1750980	NM_003001.5(SDHC):c.-5C>A	SDHC	Single nucleotide variant (5 prime UTR variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 486435	NM_003001.5(SDHC):c.-4C>T	SDHC	Single nucleotide variant (5 prime UTR variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 232369	NM_003001.5(SDHC):c.-3A>G	SDHC	Single nucleotide variant (5 prime UTR variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 1784205	NM_003001.5(SDHC):c.-1G>A	SDHC	Single nucleotide variant (5 prime UTR variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 407060	NM_003001.5(SDHC):c.1A>G (p.Met1Val)	SDHC (M1V)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +3 more	GPathogenic
Select item 465977	NM_003001.5(SDHC):c.4G>A (p.Ala2Thr)	SDHC (A2T)	Single nucleotide variant (missense variant)	Gastrointestinal stromal tumor +2 more	GUncertain significance
Select item 2625945	NM_003001.5(SDHC):c.5C>T (p.Ala2Val)	SDHC (A2V)	Single nucleotide variant (missense variant +2 more)	Paragangliomas 3 +2 more	GUncertain significance
Select item 663942	NM_003001.5(SDHC):c.5C>G (p.Ala2Gly)	SDHC (A2G)	Single nucleotide variant (missense variant)	Gastrointestinal stromal tumor +2 more	GUncertain significance
Select item 1570436	NM_003001.5(SDHC):c.6T>G (p.Ala2=)	SDHC	Single nucleotide variant (synonymous variant +2 more)	Gastrointestinal stromal tumor +2 more	GLikely benign
Select item 220994	NM_003001.5(SDHC):c.6T>C (p.Ala2=)	SDHC	Single nucleotide variant (synonymous variant +2 more)	Gastrointestinal stromal tumor +3 more	GLikely benign
Select item 189840	NM_003001.5(SDHC):c.6del (p.Ala3fs)	SDHC (A3fs)	Deletion (frameshift variant)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 407063	NM_003001.5(SDHC):c.7G>A (p.Ala3Thr)	SDHC (A3T)	Single nucleotide variant (missense variant)	Gastrointestinal stromal tumor +4 more	GUncertain significance
Select item 407053	NM_003001.5(SDHC):c.7G>T (p.Ala3Ser)	SDHC (A3S)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +4 more	GUncertain significance
Select item 161387	NM_003001.5(SDHC):c.8C>T (p.Ala3Val)	SDHC (A3V)	Single nucleotide variant (missense variant)	Paragangliomas 3 +5 more	GUncertain significance
Select item 1768940	NM_003001.5(SDHC):c.9G>T (p.Ala3=)	SDHC	Single nucleotide variant (synonymous variant +2 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 696707	NM_003001.5(SDHC):c.9G>A (p.Ala3=)	SDHC	Single nucleotide variant (synonymous variant +2 more)	Gastrointestinal stromal tumor +4 more	GLikely benign
Select item 2926321	NM_003001.5(SDHC):c.10C>T (p.Leu4=)	SDHC	Single nucleotide variant (synonymous variant +2 more)	Hereditary cancer-predisposing syndrome +2 more	GLikely benign
Select item 371802	NM_003001.5(SDHC):c.11T>C (p.Leu4Pro)	SDHC (L4P)	Single nucleotide variant (missense variant)	not provided +3 more	GUncertain significance
Select item 993236	NM_003001.5(SDHC):c.12G>T (p.Leu4=)	SDHC	Single nucleotide variant (synonymous variant +2 more)	Paragangliomas 3 +4 more	GLikely benign
Select item 663454	NM_003001.5(SDHC):c.13T>A (p.Leu5Met)	SDHC (L5M)	Single nucleotide variant (missense variant)	Gastrointestinal stromal tumor +3 more	GUncertain significance
Select item 577464	NM_003001.5(SDHC):c.14T>C (p.Leu5Ser)	SDHC (L5S)	Single nucleotide variant (missense variant)	not provided +4 more	GUncertain significance
Select item 184591	NM_003001.5(SDHC):c.15G>T (p.Leu5Phe)	SDHC (L5F)	Single nucleotide variant (missense variant)	Hereditary pheochromocytoma-paraganglioma +4 more	GUncertain significance
Select item 1376152	NM_003001.5(SDHC):c.20+4del	SDHC	Deletion (5 prime UTR variant +1 more)	Gastrointestinal stromal tumor +2 more	GUncertain significance
Select item 957116	NM_003001.5(SDHC):c.20+5C>T	SDHC	Single nucleotide variant (5 prime UTR variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 44647	NM_003001.3(SDHC):c.20+11_20+12dup	MPZ, SDHC	Duplication (5 prime UTR variant +1 more)	Roussy-Lévy syndrome +9 more	GBenign
Select item 1786262	NM_003001.5(SDHC):c.21-22_30dup	SDHC	Duplication (splice acceptor variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 428936	NM_003001.5(SDHC):c.21-2A>G	SDHC	Single nucleotide variant (splice acceptor variant +1 more)	Gastrointestinal stromal tumor +3 more	GPathogenic/Likely pathogenic
Select item 1513452	NM_003001.5(SDHC):c.22C>A (p.His8Asn)	SDHC (H8N)	Single nucleotide variant (missense variant +3 more)	Paragangliomas 3 +2 more	GUncertain significance
Select item 465965	NM_003001.5(SDHC):c.22C>T (p.His8Tyr)	SDHC (H8Y)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 1042345	NM_003001.5(SDHC):c.23A>G (p.His8Arg)	SDHC (H8R)	Single nucleotide variant (missense variant +3 more)	Gastrointestinal stromal tumor +2 more	GUncertain significance
Select item 465968	NM_003001.5(SDHC):c.24C>T (p.His8=)	SDHC	Single nucleotide variant (synonymous variant +3 more)	not provided +3 more	GLikely benign
Select item 465967	NM_003001.5(SDHC):c.24C>A (p.His8Gln)	SDHC (H8Q)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 3223028	NM_003001.5(SDHC):c.25G>C (p.Val9Leu)	SDHC (V9L)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 239451	NM_003001.5(SDHC):c.25G>A (p.Val9Ile)	SDHC (V9I)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 465971	NM_003001.5(SDHC):c.30T>C (p.Gly10=)	SDHC	Single nucleotide variant (synonymous variant +3 more)	Hereditary cancer-predisposing syndrome +2 more	GLikely benign
Select item 577853	NM_003001.5(SDHC):c.31C>T (p.Arg11Cys)	SDHC (R11C)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome +4 more	GUncertain significance
Select item 187333	NM_003001.5(SDHC):c.32G>T (p.Arg11Leu)	SDHC (R11L)	Single nucleotide variant (missense variant +3 more)	Gastrointestinal stromal tumor +4 more	GUncertain significance
Select item 1002746	NM_003001.5(SDHC):c.34C>G (p.His12Asp)	SDHC (H12D)	Single nucleotide variant (missense variant +3 more)	Gastrointestinal stromal tumor +2 more	GUncertain significance
Select item 824356	NM_003001.5(SDHC):c.38G>C (p.Cys13Ser)	SDHC (C13S)	Single nucleotide variant (intron variant +3 more)	Paragangliomas 3 +2 more	GUncertain significance
Select item 439297	NM_003001.5(SDHC):c.40C>T (p.Leu14Phe)	SDHC (L14F)	Single nucleotide variant (missense variant +3 more)	Hereditary pheochromocytoma-paraganglioma +4 more	GUncertain significance
Select item 534380	NM_003001.5(SDHC):c.42C>T (p.Leu14=)	SDHC	Single nucleotide variant (synonymous variant +3 more)	Gastrointestinal stromal tumor +4 more	GConflicting classifications of pathogenicity
Select item 1386907	NM_003001.5(SDHC):c.43C>G (p.Arg15Gly)	SDHC (R15G)	Single nucleotide variant (missense variant +3 more)	Gastrointestinal stromal tumor +3 more	GUncertain significance
Select item 41776	NM_003001.5(SDHC):c.43C>T (p.Arg15Ter)	SDHC (R15*)	Single nucleotide variant (nonsense +3 more)	Paragangliomas 3 +4 more	GPathogenic
Select item 655251	NM_003001.5(SDHC):c.44G>A (p.Arg15Gln)	SDHC (R15Q)	Single nucleotide variant (missense variant +3 more)	Gastrointestinal stromal tumor +3 more	GUncertain significance
Select item 1094327	NM_003001.5(SDHC):c.45A>T (p.Arg15=)	SDHC	Single nucleotide variant (synonymous variant +3 more)	Hereditary cancer-predisposing syndrome +2 more	GLikely benign
Select item 663196	NM_003001.5(SDHC):c.46G>A (p.Ala16Thr)	SDHC (A16T)	Single nucleotide variant (missense variant +3 more)	Gastrointestinal stromal tumor +3 more	GUncertain significance
Select item 515256	NM_003001.5(SDHC):c.48C>G (p.Ala16=)	SDHC	Single nucleotide variant (synonymous variant +3 more)	Gastrointestinal stromal tumor +4 more	GLikely benign
Select item 3223034	NM_003001.5(SDHC):c.50A>G (p.His17Arg)	SDHC (H17R)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 825438	NM_003001.5(SDHC):c.50A>T (p.His17Leu)	SDHC (H17L)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 825536	NM_003001.5(SDHC):c.51C>A (p.His17Gln)	SDHC (H17Q)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 232892	NM_003001.5(SDHC):c.54T>G (p.Phe18Leu)	SDHC (F18L)	Single nucleotide variant (missense variant +3 more)	Hereditary pheochromocytoma-paraganglioma +3 more	GConflicting classifications of pathogenicity
Select item 2561491	NM_003001.5(SDHC):c.58C>G (p.Pro20Ala)	SDHC (P20A)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 2493307	NM_003001.5(SDHC):c.58C>T (p.Pro20Ser)	SDHC (P20S)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 1313634	NM_003001.5(SDHC):c.59C>G (p.Pro20Arg)	SDHC (P20R)	Single nucleotide variant (missense variant +3 more)	not provided +1 more	GUncertain significance
Select item 480864	NM_003001.5(SDHC):c.61C>G (p.Gln21Glu)	SDHC (Q21E)	Single nucleotide variant (missense variant +3 more)	Hereditary pheochromocytoma-paraganglioma +3 more	GUncertain significance
Select item 3223035	NM_003001.5(SDHC):c.62A>T (p.Gln21Leu)	SDHC (Q21L)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3223036	NM_003001.5(SDHC):c.63G>C (p.Gln21His)	SDHC (Q21H)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 465978	NM_003001.5(SDHC):c.64C>T (p.Leu22Phe)	SDHC (L22F)	Single nucleotide variant (missense variant +3 more)	not provided +3 more	GUncertain significance
Select item 1083283	NM_003001.5(SDHC):c.66C>T (p.Leu22=)	SDHC	Single nucleotide variant (synonymous variant +3 more)	Gastrointestinal stromal tumor +2 more	GLikely benign
Select item 2625384	NM_003001.5(SDHC):c.68G>A (p.Cys23Tyr)	SDHC (C23Y)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 239457	NM_003001.5(SDHC):c.73A>G (p.Arg25Gly)	SDHC (R25G)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 933779	NM_003001.5(SDHC):c.76A>G (p.Asn26Asp)	SDHC (N26D)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 2442320	NM_003001.5(SDHC):c.77+1G>C	SDHC	Single nucleotide variant (splice donor variant +1 more)	Paragangliomas 3 +1 more	GPathogenic/Likely pathogenic
Select item 837072	NM_003001.5(SDHC):c.77+2dup	SDHC	Duplication (splice donor variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GConflicting classifications of pathogenicity
Select item 827209	NM_003001.5(SDHC):c.77+1G>A	SDHC	Single nucleotide variant (splice donor variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GLikely pathogenic
Select item 827210	NM_003001.5(SDHC):c.77+5G>T	SDHC	Single nucleotide variant (intron variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 1570658	NM_003001.5(SDHC):c.78-16T>C	SDHC	Single nucleotide variant (intron variant)	Gastrointestinal stromal tumor +2 more	GConflicting classifications of pathogenicity
Select item 534370	NM_003001.5(SDHC):c.78-1G>T	SDHC	Single nucleotide variant (splice acceptor variant +1 more)	Gastrointestinal stromal tumor +2 more	GLikely pathogenic
Select item 185473	NM_003001.5(SDHC):c.78-1G>A	SDHC	Single nucleotide variant (splice acceptor variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely pathogenic
Select item 231683	NM_003001.5(SDHC):c.81T>C (p.Ala27=)	SDHC	Single nucleotide variant (synonymous variant +3 more)	Gastrointestinal stromal tumor +2 more	GLikely benign
Select item 640580	NM_003001.5(SDHC):c.82G>A (p.Val28Ile)	SDHC (V28I +1 more)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome +4 more	GUncertain significance
Select item 583030	NM_003001.5(SDHC):c.82G>T (p.Val28Phe)	SDHC (V28F +1 more)	Single nucleotide variant (missense variant +3 more)	Paragangliomas 3 +3 more	GUncertain significance
Select item 239458	NM_003001.5(SDHC):c.85C>G (p.Pro29Ala)	SDHC (P29A +1 more)	Single nucleotide variant (missense variant +3 more)	Hereditary pheochromocytoma-paraganglioma +5 more	GUncertain significance
Select item 465980	NM_003001.5(SDHC):c.94A>G (p.Thr32Ala)	SDHC (T32A +1 more)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 1767917	NM_003001.5(SDHC):c.97_98dup (p.Ala34fs)	SDHC (A34fs +1 more)	Duplication (frameshift variant +3 more)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 823362	NM_003001.5(SDHC):c.95C>A (p.Thr32Asn)	SDHC (T32N +1 more)	Single nucleotide variant (missense variant +3 more)	Paragangliomas 3 +2 more	GUncertain significance
Select item 965823	NM_003001.5(SDHC):c.97A>G (p.Thr33Ala)	SDHC (T33A +1 more)	Single nucleotide variant (missense variant +3 more)	Gastrointestinal stromal tumor +2 more	GUncertain significance
Select item 407054	NM_003001.5(SDHC):c.98C>T (p.Thr33Met)	SDHC (T33M +1 more)	Single nucleotide variant (missense variant +3 more)	not provided +6 more	GUncertain significance
Select item 534382	NM_003001.5(SDHC):c.99G>T (p.Thr33=)	SDHC	Single nucleotide variant (synonymous variant +3 more)	Gastrointestinal stromal tumor +3 more	GLikely benign
Select item 486428	NM_003001.5(SDHC):c.99G>A (p.Thr33=)	SDHC	Single nucleotide variant (synonymous variant +3 more)	SDHC-related condition +4 more	GConflicting classifications of pathogenicity
Select item 818288	NM_003001.5(SDHC):c.102C>T (p.Ala34=)	SDHC	Single nucleotide variant (synonymous variant +3 more)	Hereditary cancer-predisposing syndrome +2 more	GLikely benign
Select item 822072	NM_003001.5(SDHC):c.103A>G (p.Lys35Glu)	SDHC (K35E +1 more)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 822074	NM_003001.5(SDHC):c.104A>G (p.Lys35Arg)	SDHC (K35R +1 more)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 1082756	NM_003001.5(SDHC):c.108A>G (p.Glu36=)	SDHC	Single nucleotide variant (synonymous variant +3 more)	Hereditary cancer-predisposing syndrome +2 more	GLikely benign
Select item 1040508	NM_003001.5(SDHC):c.110A>T (p.Glu37Val)	SDHC (E37V +1 more)	Single nucleotide variant (missense variant +3 more)	Gastrointestinal stromal tumor +2 more	GUncertain significance
Select item 1797310	NM_003001.5(SDHC):c.111G>A (p.Glu37=)	SDHC	Single nucleotide variant (synonymous variant +3 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 534373	NM_003001.5(SDHC):c.114G>C (p.Met38Ile)	SDHC (M38I +2 more)	Single nucleotide variant (missense variant +3 more)	Gastrointestinal stromal tumor +2 more	GUncertain significance
Select item 1739059	NM_003001.5(SDHC):c.116A>G (p.Glu39Gly)	SDHC (E20G +2 more)	Single nucleotide variant (intron variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 407049	NM_003001.5(SDHC):c.116A>C (p.Glu39Ala)	SDHC (E39A +2 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 1744549	NM_003001.5(SDHC):c.118del (p.Arg40fs)	SDHC (R40fs +2 more)	Deletion (frameshift variant +2 more)	Paragangliomas 3 +1 more	GPathogenic
Select item 534374	NM_003001.5(SDHC):c.118C>T (p.Arg40Trp)	SDHC (R40W +2 more)	Single nucleotide variant (missense variant +2 more)	Gastrointestinal stromal tumor +4 more	GUncertain significance
Select item 239446	NM_003001.5(SDHC):c.119G>A (p.Arg40Gln)	SDHC (R40Q +2 more)	Single nucleotide variant (missense variant +2 more)	not provided +4 more	GUncertain significance
Select item 1113772	NM_003001.5(SDHC):c.120G>C (p.Arg40=)	SDHC	Single nucleotide variant (synonymous variant +2 more)	Paragangliomas 3 +2 more	GLikely benign
Select item 239447	NM_003001.5(SDHC):c.120G>A (p.Arg40=)	SDHC	Single nucleotide variant (synonymous variant +2 more)	Paragangliomas 3 +5 more	GBenign/Likely benign
Select item 852254	NM_003001.5(SDHC):c.122T>C (p.Phe41Ser)	SDHC (F41S +2 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 534372	NM_003001.5(SDHC):c.127A>C (p.Asn43His)	SDHC (N43H +2 more)	Single nucleotide variant (missense variant +2 more)	Gastrointestinal stromal tumor +3 more	GUncertain significance
Select item 1769052	NM_003001.5(SDHC):c.128A>T (p.Asn43Ile)	SDHC (N24I +2 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 239448	NM_003001.5(SDHC):c.128A>G (p.Asn43Ser)	SDHC (N43S +2 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome +4 more	GUncertain significance
Select item 1082605	NM_003001.5(SDHC):c.132G>A (p.Lys44=)	SDHC	Single nucleotide variant (synonymous variant +2 more)	Hereditary cancer-predisposing syndrome +2 more	GLikely benign

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